This executive summary for the Industry Clusters 2022 Update project, which includes Pandemic Impacts on Centralina’s Industry Clusters; Key Findings from the Assessments: Target Industry Performance Assessment and Cluster Analysis, Macro Forces and Industry Disruptors, Supply Chain Analysis and Artificial Intelligence (AI) Automation Risk Assessment; and Insights for the CEDS Update and was funded by an EDA CARES Act Recovery Assistance Addendum Partnership Planning grant.